What Is Pro-UROL?
Pro-UROL is a Canadian natural health product in tablet form. The facts below come from Health Canada's Licensed Natural Health Products Database (LNHPD), checked 29 September 2026.
| Brand name | Pro-UROL |
| NPN | 80147704 |
| Licence holder | Aleaf Labs Inc. |
| Licence status | Active; licensed 6 March 2026 |
| Dosage form | Tablet, oral |
| Dose | Men 18 and older: 1 tablet, 3 times daily |
| Medicinal ingredients per tablet | Quercetin 400 mg; pollen extract 120 mg (10:1, equivalent to 1,200 mg dried pollen); papain 50 mg (100,000 FCC PU); stem bromelain 33.33 mg (1,200,000 FCC PU) |
| Non-medicinal ingredients | Colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose |
| Recommended use | "Source of/Provides antioxidants. Helps to support prostate health. Helps relieve the pain of non-bacterial chronic Prostatitis. Helps relieve pain associated with chronic prostatitis to support quality of life." |
| Cautions | Ask a health care practitioner before use if you take a blood thinner, anti-inflammatory drugs or antibiotics; have a stomach or intestinal ulcer or lesion; are having surgery; or are allergic to latex or certain fruits (avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, tomato) |
| Contraindication | Do not use if you are allergic to bee products or pollen |
| Duration of use | None stated on the licence record |
Keep three kinds of claim separate. Licensed claims are the words above that Health Canada authorized; they are not a promise that the product will work for you. Marketing is anything a company says beyond the licence, including us. Clinical evidence is what trials show, and for Pro-UROL all of it concerns individual ingredients.
The public licence record does not name the manufacturer or the plant source of the pollen extract. Compare the NPN and medicinal ingredients on any bottle with the table above. Similar names belong to different products: Farr Laboratories' PROUROL is a probiotic, and Prosturol is sold by other companies in Germany and the U.S.
Pro-UROL Ingredients: Dose and Evidence
Two of the four ingredients, quercetin and pollen extract, have been tested in randomized trials in men with CP/CPPS. Bromelain and papain have not. Daily amounts are per-tablet amounts × 3.
| Ingredient | Per day | CP/CPPS evidence | Limitation |
|---|---|---|---|
| Quercetin | 1,200 mg | One randomized trial: 30 men, 500 mg twice daily (1,000 mg/day) for 1 month. Symptom scores fell from 21.0 to 13.1 on quercetin vs 20.2 to 18.8 on placebo; 67% vs 20% improved by at least 25% (Shoskes 1999). | One small, short trial, not replicated in a large trial. Pro-UROL's dose is 20% higher than the dose studied. |
| Pollen extract | 360 mg (10:1; 3,600 mg pollen equivalent) | One randomized trial: 139 men with inflammatory CP/CPPS took Cernilton, about 378 mg/day, for 12 weeks. 70.6% responded vs 50.0% on placebo (Wagenlehner 2009). | The trial used Cernilton, a specific rye-grass pollen extract. The milligrams are similar, but the extracts may not be equivalent. Only the inflammatory subtype was studied. |
| Stem bromelain | 100 mg | No CP/CPPS trial on its own. | Better absorption of quercetin is a theory, not a shown benefit. Adds bleeding and allergy risk. |
| Papain | 150 mg | No CP/CPPS trial on its own. | Same unproven theory; carries the latex–fruit allergy caution. |
The trials lasted 4 and 12 weeks. That is a sensible window to reassess, not a guarantee of results.
Safety and interactions
- Quercetin is usually well tolerated at up to 1,000 mg a day for 12 weeks. In laboratory studies it affects enzymes that break down some drugs, and one case report linked it to a higher INR in a person on warfarin. Kidney damage has been reported with high intravenous doses.
- Quinolone antibiotics and kidney disease: Urolo-Q, a similar Canadian product, carries licensed cautions for both. Pro-UROL's licence does not, but if you take ciprofloxacin, levofloxacin or a similar antibiotic, or have kidney disease, ask your pharmacist before use.
- Bromelain and papain can add to bleeding risk with blood thinners or before surgery, and can trigger allergy in people sensitive to latex or certain fruits.
- Pollen extract: do not use if you are allergic to pollen or bee products. Mild stomach upset has been reported.
Does Pro-UROL Itself Have Clinical Evidence?
No. We found no published or registered trial of Pro-UROL, and Aleaf Labs has not run one.
A finished-product trial gives men the actual tablet at the labelled dose and compares it with placebo. An ingredient trial tests one component, often a specific branded version. It shows whether that component can help, not whether a different product with a different source, amount or combination will. It is reasonable to expect a product combining two ingredients that each helped in trials to help too. It is not proven, and combining ingredients can add side effects without adding benefit.
The closest data come from an open-label follow-up to the 1999 quercetin trial: 17 men took a quercetin, bromelain and papain supplement and 82% improved by at least 25%. There was no placebo group, so expectation and the natural ups and downs of CP/CPPS may explain part of that, and it was a different product. A trial of the similar U.S. product Q-Urol is registered in men with radiation-related prostate symptoms after brachytherapy (NCT04252625). That is a different condition and a different product, and we found no published results. If Pro-UROL is ever tested, the result belongs in this article, whatever it shows.
What the 2025 AUA Guideline Does and Does Not Say
The American Urological Association's 2025 guideline states that clinicians "may prescribe phytotherapeutics including saw palmetto, quercetin, and pollen extract to improve pain, voiding symptoms, and quality of life" (Conditional Recommendation, Grade B). That allows clinicians to consider these ingredients. It names ingredients, not brands, so it does not endorse Pro-UROL or any other product. It also does not rank supplements above pelvic floor physiotherapy, shockwave therapy or an alpha-blocker. A Cochrane review of seven plant-based treatment trials found an average symptom-score improvement of about 5 points versus placebo, with low certainty. See what the broader supplement evidence shows and the full list of treatment options.
What an NPN Means, and What It Does Not
An NPN means Health Canada reviewed the product's ingredients, amounts, dose, claims and warnings before licensing it, and that it must be made under good manufacturing practices. Health Canada describes a licensed product as safe and effective when used according to the label. An NPN does not require a trial of the finished product; claims can rest on published evidence for the ingredients. It does not make one product better than another: Urolo-Q, NOW Quercetin with Bromelain and AOR Prostate Support also carry licensed claims for the pain of non-bacterial chronic prostatitis. And it does not mean a product treats infection, BPH or cancer. See Pro-UROL vs. Urolo-Q for the two licences side by side.
Before You Try Pro-UROL
- Get a diagnosis. A urine test and culture rule out infections that need antibiotics. CP/CPPS is diagnosed only after other causes are excluded.
- Do not use a supplement instead of urgent care if you have fever or chills, cannot urinate, have blood in your urine, or severe pain.
- Measure. Score your symptoms with the NIH-CPSI before you start and again at about 12 weeks. A drop of about 6 points is a meaningful change. If there is none, talk to your doctor about other options.
- Check interactions with your pharmacist if you take blood thinners, anti-inflammatories or antibiotics.
Frequently Asked Questions
Does Pro-UROL work for chronic prostatitis?
It has not been tested directly. Its main ingredients each helped in one small-to-moderate placebo-controlled trial in CP/CPPS. Whether it helps you can only be judged by trying it for a set period and measuring the change.
Can Pro-UROL treat a prostate infection?
No. Bacterial prostatitis needs antibiotics chosen from a culture result.
Will Pro-UROL shrink my prostate or help BPH?
It is not licensed for BPH, and there is no good evidence that its ingredients shrink the prostate.
Does it prevent prostate cancer?
No. Easing pelvic or urinary symptoms says nothing about cancer risk.
How long should I take it before deciding?
About 12 weeks, the length of the longer trial. One 90-tablet bottle lasts 30 days at 3 tablets a day.
Is Pro-UROL the same as Q-Urol or Urolo-Q?
No. They share the same four ingredients, at different amounts, from different companies.
How do I know I have the genuine product?
The bottle should show NPN 80147704, and its medicinal ingredients should match the licence record above.