The Science Behind Pro-UROL

Chronic non-bacterial prostatitis (CP/CPPS) doesn’t respond reliably to antibiotics. The 2025 AUA guideline update recognizes phytotherapy as part of the evidence base for CP/CPPS management — that’s the territory Pro-UROL was built for.

What is CP/CPPS?

Chronic pelvic or perineal pain
Urinary urgency or frequency
Pain during or after ejaculation
Symptoms lasting 3+ months

CP/CPPS (Category III prostatitis) is the most common prostatitis syndrome in men, accounting for over 90% of prostatitis diagnoses. It is characterized by pelvic pain and urinary symptoms in the absence of bacterial infection — making antibiotics largely ineffective and leaving many men without a reliable treatment path.

Formulation rationale

Each active is included at a dose informed by published research on its respective compound class — not an arbitrary proprietary blend amount.

Quercetin

A bioflavonoid evaluated in clinical studies for chronic pelvic pain symptom scores (NIH-CPSI). Included at the dose used in published CP/CPPS trials for its anti-inflammatory and antioxidant properties within prostate tissue.

400mg · as Quercetin dihydrate

Rye Pollen Extract

Cernitin-type rye pollen extracts are among the most studied botanicals for CP/CPPS, with multiple controlled trials assessing pelvic pain and urinary symptom scores over 12–24 weeks. Standardized 10:1 extract ensures consistent potency.

120mg · Secale cereale 10:1 · equiv. 1,200mg dry

Papain

A proteolytic enzyme derived from papaya fruit, included for its systemic anti-inflammatory activity. Enzyme activity is measured in FCC PU to ensure consistent potency across batches.

100,000 FCC PU · Carica papaya fruit

Stem Bromelain

A proteolytic enzyme complex derived from pineapple stem, studied for anti-inflammatory and tissue-support properties. Paired with papain to provide complementary enzymatic anti-inflammatory activity relevant to pelvic and prostate tissue.

1,200,000 FCC PU · Ananas comosus stem

Medicinal ingredients and quantities as licensed by Health Canada under NPN 80147704. Full ingredient list, exact quantities, and non-medicinal ingredients are printed on the product label and Health Canada licensing documentation. This page describes formulation rationale, not individual clinical claims for Pro-UROL itself.

Why Pro-UROL

Pro-UROL is the only Health Canada-licensed NHP with an authorized indication specifically for CP/CPPS symptomatic support. It combines quercetin, rye pollen extract, bromelain, and papain — a four-ingredient formula with transparent doses, a defined 90-day treatment course, and a clinical evidence base recognized by the American Urological Association.

How Pro-UROL compares to other licensed options in Canada →

See the science

Pro-UROL is formulated using ingredients with peer-reviewed CP/CPPS trial data. The quercetin evidence base includes NIH-CPSI validated outcomes. The rye pollen extract evidence base spans 12–24 week placebo-controlled trials. Both are recognized in the 2025 AUA phytotherapy guideline update.

Quercetin for CP/CPPS: AUA Guidelines, Clinical Trial Data & Mechanisms of Action → Pro-UROL Clinical Review: Rye Pollen Extract & the 90-Day Treatment Course →

Quality & manufacturing

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GMP-certified facility

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Health Canada NPN 80147704

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Certificates of Analysis available on request

For healthcare providers

Want the full monograph and study citations?

We provide a detailed clinical reference sheet to pharmacists and urology clinics on request, including full PubMed citations, ingredient monographs, and the Health Canada licensing summary for NPN 80147704.

Request the clinical sheet →